Icosanoid catabolic process

Across TCGA cell cohorts, RNA activity of the Icosanoid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TM7SF3, CEP85L, and APEX2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Icosanoid catabolic process activity versus TM7SF3 in LUNG_NSCLC_LUAD (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TM7SF3 →	+1.075	+1.274	<.001	.002	3	3
LARGE_INTESTINE	CEP85L →	-0.703	-0.998	.004	.002	3	3
OESOPHAGUS	APEX2 →	+0.693	+1.620	.006	<.001	3	2
URINARY_TRACT	SLC35B2 →	+1.030	+1.705	.002	.002	2	3
BLOOD_Leukemia	ZNF664 →	-0.590	-1.174	.007	.009	3	2
PANCREAS	CCDC61 →	+0.830	+1.759	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901523 vs TM7SF3 — LUNG_NSCLC_LUAD

Explore this scatter interactively →