Regulation of endothelial tube morphogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of endothelial tube morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPM3, PRKCZ, and RASGRP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NPM3 grouped by Regulation of endothelial tube morphogenesis-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NPM3 →	+0.820	+0.956	.005	.005	3	5
LIVER	PRKCZ →	+2.170	+1.570	.001	<.001	3	5
SKIN	RASGRP3 →	-1.313	-1.192	.001	<.001	3	5
SKIN	DCUN1D4 →	-0.645	-1.124	<.001	.003	3	4
KIDNEY	TTC17 →	-0.731	-1.539	<.001	.001	3	4
PANCREAS	USP1 →	-0.613	-1.287	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NPM3 by Regulation of endothelial tube morphogenesis activity — LARGE_INTESTINE

Explore this box plot interactively →