Ether biosynthetic process

Across TCGA patient cohorts, RNA activity of the Ether biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPS5, SPTBN1_S257, and NXF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ether biosynthetic process activity versus RPS5 in GBM (Pearson r = -0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPS5 →	-0.233	-0.056	<.001	<.001	3	6
LSCC	SPTBN1_S257 →	+0.550	+0.056	<.001	<.001	3	6
GBM	NXF1 →	-0.277	-0.052	<.001	<.001	3	6
GBM	ASPA →	+0.685	+0.056	.002	<.001	3	5
BRCA	SYNPO2 →	+0.476	+0.034	<.001	<.001	3	5
GBM	EPB41L2 →	+0.410	+0.056	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901503 vs RPS5 — GBM

Explore this scatter interactively →