Positive regulation of voltage-gated calcium channel activity

Across TCGA patient cohorts, RNA activity of the Positive regulation of voltage-gated calcium channel activity pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBLN2, CAMK2A, and CNTN4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of voltage-gated calcium channel activity activity versus FBLN2 in HNSC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FBLN2 →	+1.036	+0.362	.007	.003	3	5
GBM	CAMK2A →	+2.213	+1.142	<.001	<.001	3	5
GBM	CNTN4 →	+0.462	+0.599	.002	.002	3	4
BRCA	PRRX1 →	+1.054	+1.116	<.001	<.001	3	4
BRCA	SLC41A2 →	+0.607	+0.523	.003	.009	3	4
GBM	DOK6 →	+0.653	+0.691	.005	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901387 vs FBLN2 — HNSC

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