Regulation of voltage-gated calcium channel activity

Across TCGA patient cohorts, RNA activity of the Regulation of voltage-gated calcium channel activity pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAPRE3_S162, NCOA7_S173, and MAPRE3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of voltage-gated calcium channel activity activity versus MAPRE3_S162 in GBM (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MAPRE3_S162 →	+0.372	+0.047	<.001	<.001	3	5
OV	NCOA7_S173 →	+0.492	+0.028	.004	.002	3	4
GBM	MAPRE3 →	+0.331	+0.043	<.001	<.001	3	4
GBM	TMEM30A →	+0.535	+0.063	<.001	<.001	3	4
COAD	UBE2O_S399 →	+0.604	+0.039	<.001	<.001	3	4
BRCA	S100A1 →	+0.942	+0.027	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901385 vs MAPRE3_S162 — GBM

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