Regulation of voltage-gated calcium channel activity

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of voltage-gated calcium channel activity pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 35 member genes.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher Regulation of voltage-gated calcium channel activity pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and LUAD, show the opposite pattern, with higher activity associated with better survival.

STAD, UVM, and HNSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Tertile	III,IV	0.480	0.696	.001	117	view →
UVM	OS	Median	II,III,IV	0.805	0.454	.001	105	view →
HNSC	DFS	Tertile	III,IV	0.555	0.762	<.001	73	view →
SCLC	DFS	Median	All	0.566	0.928	.003	32	view →
LUAD	OS	Median	II,III,IV	0.593	0.350	.014	26	view →
BLCA	OS	Median	III,IV	0.284	0.558	.003	24	view →
KIRP	DFS	Quartile	All	0.979	0.818	.004	22	view →
KICH	OS	Tertile	All	0.601	1.000	.006	21	view →
UCS	DFS	Tertile	II,III,IV	0.562	0.223	.024	18	view →
ACC	OS	Tertile	II,III,IV	0.435	0.779	.018	13	view →
READ	OS	Median	IV	0.606	1.000	<.001	13	view →
SKCM	DFS	Tertile	III,IV	0.165	0.326	.007	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:1901385–STAD (OS)

Open the STAD breakdown →