Regulation of voltage-gated calcium channel activity

Across TCGA patient cohorts, RNA activity of the Regulation of voltage-gated calcium channel activity pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AHNAK, RAD54L, and FANCA, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of voltage-gated calcium channel activity activity versus AHNAK in LSCC (Pearson r = -0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AHNAK →	+0.690	+1.305	<.001	<.001	3	8
LUAD	RAD54L →	-0.722	-1.247	<.001	<.001	3	8
GBM	FANCA →	-0.788	-1.205	.001	.001	3	7
GBM	WDR62 →	-0.811	-1.105	.002	.002	3	7
LUAD	HELLS →	-0.669	-1.182	<.001	<.001	3	6
UCEC	EMP1 →	+0.989	+1.002	<.001	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901385 vs AHNAK — LSCC

Explore this scatter interactively →