Regulation of voltage-gated calcium channel activity

Across TCGA cell cohorts, RNA activity of the Regulation of voltage-gated calcium channel activity pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FANCC, CENPO, and UBE2V2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FANCC grouped by Regulation of voltage-gated calcium channel activity-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	FANCC →	+0.701	+0.951	.008	.006	3	6
LIVER	CENPO →	+0.846	+1.636	.002	<.001	3	5
LIVER	UBE2V2 →	+0.731	+1.123	.004	.004	3	5
OVARY	DNMT1 →	+0.990	+1.138	.001	<.001	3	4
LARGE_INTESTINE	TMEM242 →	+0.353	+0.893	.004	.002	3	4
LIVER	EXOSC9 →	+0.621	+1.310	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FANCC by Regulation of voltage-gated calcium channel activity activity — OVARY

Explore this box plot interactively →