Regulation of voltage-gated calcium channel activity

Across TCGA cell cohorts, RNA activity of the Regulation of voltage-gated calcium channel activity pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEC14L3, ATG14, and CDKN2B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SEC14L3 grouped by Regulation of voltage-gated calcium channel activity-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SEC14L3 →	+0.273	+1.864	<.001	<.001	3	3
LUNG_SCLC	ATG14 →	+0.294	+0.239	.001	.001	3	3
LUNG_SCLC	CDKN2B →	-0.154	-0.215	.008	<.001	3	3
LUNG_SCLC	KDM1A →	+0.286	+0.180	.003	.004	3	3
BREAST	GNPTAB →	+0.134	+0.651	.004	.008	3	3
BLOOD_Leukemia	FGB →	+0.503	+1.744	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SEC14L3 by Regulation of voltage-gated calcium channel activity activity — BLOOD_Leukemia

Explore this box plot interactively →