Regulation of voltage-gated calcium channel activity

Across TCGA cell cohorts, RNA activity of the Regulation of voltage-gated calcium channel activity pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D10B, CCNL1, and TCEANC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of voltage-gated calcium channel activity activity versus TBC1D10B in OESOPHAGUS (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TBC1D10B →	+0.597	+0.213	.007	.002	3	4
BLOOD_Lymphoma	CCNL1 →	+1.101	+1.051	.002	.003	3	4
BLOOD_Lymphoma	TCEANC →	+0.679	+0.992	.002	<.001	3	4
BLOOD_Leukemia	ERV3-1 →	+1.227	+1.093	.001	.002	3	4
OVARY	EPHX2 →	-2.070	-0.264	.006	.003	3	3
OVARY	ARF1 →	+0.848	+0.325	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901385 vs TBC1D10B — OESOPHAGUS

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