Positive regulation of potassium ion transmembrane transport

Across TCGA patient cohorts, RNA activity of the Positive regulation of potassium ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKT3, LMOD1, and SEPTIN4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of potassium ion transmembrane transport activity versus AKT3 in CCRCC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	AKT3 →	+0.621	+0.588	<.001	<.001	3	8
CCRCC	LMOD1 →	+1.313	+0.685	<.001	<.001	3	8
CCRCC	SEPTIN4 →	+0.728	+0.542	<.001	<.001	3	7
BRCA	CNRIP1 →	+0.858	+0.660	<.001	<.001	3	7
CCRCC	RHOJ →	+0.714	+0.609	<.001	<.001	3	7
OV	AOC3 →	+1.105	+0.893	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901381 vs AKT3 — CCRCC

Explore this scatter interactively →