Positive regulation of potassium ion transmembrane transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of potassium ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNN4, UBE2O, and TIMELESS, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of potassium ion transmembrane transport activity versus KCNN4 in LIVER (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	KCNN4 →	+3.098	+0.138	<.001	.005	3	14
BLOOD_Lymphoma	UBE2O →	-1.111	-0.112	<.001	.002	3	14
SOFT_TISSUE	TIMELESS →	-1.338	-0.183	<.001	<.001	3	14
SKIN	ADAM11 →	-1.185	-0.186	<.001	<.001	3	13
BONE	ZNF764 →	-1.093	-0.115	<.001	.007	3	13
BLOOD_Lymphoma	UBTF →	-1.207	-0.168	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901381 vs KCNN4 — LIVER

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