Regulation of potassium ion transmembrane transport

Across TCGA patient cohorts, RNA activity of the Regulation of potassium ion transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SUZ12, MCM2, and RFC5, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of potassium ion transmembrane transport activity versus SUZ12 in GBM (Pearson r = -0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SUZ12 →	-0.335	-0.060	<.001	.001	3	8
LSCC	MCM2 →	-0.428	-0.024	<.001	<.001	3	8
LSCC	RFC5 →	-0.311	-0.021	<.001	.001	3	8
LSCC	MAPK3 →	+0.178	+0.027	.001	.006	3	8
BRCA	RFC1 →	-0.284	-0.026	<.001	<.001	3	7
BRCA	SNRNP200 →	-0.248	-0.028	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901379 vs SUZ12 — GBM

Explore this scatter interactively →