Acetate ester transport

Across TCGA patient cohorts, RNA activity of the Acetate ester transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CEP170, PCDH1_S984, and SLC44A4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acetate ester transport activity versus CEP170 in BRCA (Pearson r = -0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CEP170 →	-0.289	-0.102	<.001	<.001	3	7
BRCA	PCDH1_S984 →	+0.714	+0.104	<.001	<.001	3	7
LUAD	SLC44A4 →	+1.278	+0.213	<.001	<.001	3	6
CCRCC	PLS1 →	+0.495	+0.230	<.001	<.001	3	6
BRCA	MYO5C →	+0.709	+0.140	<.001	<.001	3	6
UCEC	PIGR →	+0.918	+0.275	.005	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901374 vs CEP170 — BRCA

Explore this scatter interactively →