Negative regulation of vasculature development

Across TCGA cell cohorts, RNA activity of the Negative regulation of vasculature development pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-B, B2M, and SFXN4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of vasculature development activity versus HLA-B in CNS (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	HLA-B →	+3.224	+0.217	.001	<.001	3	8
LARGE_INTESTINE	B2M →	+1.975	+0.287	.001	<.001	3	6
SKIN	SFXN4 →	-0.690	-0.259	.001	.002	3	6
BREAST	TAP1 →	+1.356	+0.184	<.001	<.001	3	6
BONE	SPATS2L →	+3.122	+0.389	.002	.005	3	5
SKIN	IFI6 →	+1.783	+0.254	.003	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901343 vs HLA-B — CNS

Explore this scatter interactively →