Positive regulation of store-operated calcium channel activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of store-operated calcium channel activity pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SHOX2, PHF13, and RASSF4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SHOX2 grouped by Positive regulation of store-operated calcium channel activity-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SHOX2 →	+1.314	+1.192	<.001	<.001	3	4
KIDNEY	PHF13 →	-0.639	-1.236	.001	.001	3	4
PANCREAS	RASSF4 →	-1.286	-1.448	<.001	.001	3	3
STOMACH	LIN7B →	+1.149	+1.161	.007	.006	3	3
OVARY	ADCY9 →	-1.312	-1.248	.001	<.001	3	3
LUNG_NSCLC_LUAD	RPS6KA2 →	-1.694	-0.784	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SHOX2 by Positive regulation of store-operated calcium channel activity activity — OVARY

Explore this box plot interactively →