Regulation of odontoblast differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of odontoblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZDHHC8, SOGA1, and EPN2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZDHHC8 grouped by Regulation of odontoblast differentiation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ZDHHC8 →	-1.017	-0.292	.009	.004	3	4
SOFT_TISSUE	SOGA1 →	-1.101	-0.347	<.001	<.001	3	4
SOFT_TISSUE	EPN2 →	-1.372	-0.327	.001	.001	3	4
SOFT_TISSUE	ZNF446 →	-0.844	-0.323	.004	.002	3	4
LUNG_NSCLC_LUSC	PROM2 →	-2.935	-0.298	<.001	.003	3	4
KIDNEY	C1orf167 →	-0.886	-0.296	.005	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZDHHC8 by Regulation of odontoblast differentiation activity — LIVER

Explore this box plot interactively →