Regulation of odontoblast differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of odontoblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTC9C, SP2, and ANKH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of odontoblast differentiation activity versus TTC9C in BLOOD_Leukemia (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TTC9C →	+0.669	+0.475	<.001	.001	3	5
BLOOD_Leukemia	SP2 →	+0.411	+0.469	.003	.001	3	5
SOFT_TISSUE	ANKH →	+3.591	+0.423	.001	.001	3	4
SOFT_TISSUE	MAP3K11 →	+0.929	+0.397	.005	<.001	3	4
SOFT_TISSUE	PNPLA2 →	+1.209	+0.400	.009	.005	3	4
SOFT_TISSUE	ZBTB7A →	+0.898	+0.421	.007	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901329 vs TTC9C — BLOOD_Leukemia

Explore this scatter interactively →