Regulation of flagellated sperm motility

Across TCGA patient cohorts, RNA activity of the Regulation of flagellated sperm motility pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FERMT3, MYO1F, and TIMELESS_S1173, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of flagellated sperm motility activity versus FERMT3 in CCRCC (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	FERMT3 →	-0.262	-0.029	.002	.005	3	5
CCRCC	MYO1F →	-0.309	-0.041	.003	.003	3	5
COAD	TIMELESS_S1173 →	-0.318	-0.042	.009	.001	3	4
BRCA	TMOD1 →	+0.471	+0.039	.004	.008	3	4
COAD	ANK3 →	+0.235	+0.038	<.001	<.001	3	4
COAD	NAA35 →	-0.182	-0.040	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901317 vs FERMT3 — CCRCC

Explore this scatter interactively →