Regulation of flagellated sperm motility

Across TCGA patient cohorts, RNA activity of the Regulation of flagellated sperm motility pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEACAM21, PTPN22, and CD1C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of flagellated sperm motility activity versus CEACAM21 in UCEC (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CEACAM21 →	+1.597	+0.666	<.001	<.001	3	5
LUAD	PTPN22 →	+0.676	+0.553	.003	.005	3	5
UCEC	CD1C →	+1.239	+1.034	<.001	<.001	3	5
UCEC	CCDC150 →	-1.032	-1.107	<.001	<.001	3	5
UCEC	MCM8 →	-0.468	-0.695	<.001	<.001	3	5
UCEC	L2HGDH →	-0.658	-1.203	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901317 vs CEACAM21 — UCEC

Explore this scatter interactively →