Regulation of flagellated sperm motility

Across TCGA cell cohorts, RNA activity of the Regulation of flagellated sperm motility pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FLNC, ST14, and ST13, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FLNC grouped by Regulation of flagellated sperm motility-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	FLNC →	-0.246	-1.596	.007	.009	3	3
KIDNEY	ST14 →	+0.283	+1.945	.004	<.001	3	3
OVARY	ST13 →	+0.111	+1.683	.002	<.001	3	3
LUNG_SCLC	TTLL4 →	+0.378	+2.236	.001	<.001	3	3
LUNG_SCLC	CBX5 →	+0.463	+2.183	.001	<.001	3	2
KIDNEY	CHGA →	+0.443	+2.231	.009	<.001	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FLNC by Regulation of flagellated sperm motility activity — KIDNEY

Explore this box plot interactively →