Nucleoside phosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Nucleoside phosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UTP6, YWHAH, and OTULINL, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside phosphate biosynthetic process activity versus UTP6 in BRCA (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	UTP6 →	+0.607	+0.315	<.001	<.001	3	2
BRCA	YWHAH →	+0.753	+0.262	<.001	.002	3	2
BRCA	OTULINL →	+1.404	+0.291	.004	.007	3	2
BRCA	DNAJC7 →	+0.764	+0.284	.001	<.001	3	2
BRCA	CRLF3 →	+0.710	+0.239	.001	.008	3	2
BRCA	ALG3P1 →	-0.155	-0.287	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901293 vs UTP6 — BRCA

Explore this scatter interactively →