Nucleoside phosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Nucleoside phosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJA3, STUB1, and NDUFA5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside phosphate biosynthetic process activity versus DNAJA3 in STOMACH (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	DNAJA3 →	+0.798	+0.165	<.001	.006	3	7
BLOOD_Leukemia	STUB1 →	+0.726	+0.138	<.001	<.001	3	6
BREAST	NDUFA5 →	+0.884	+0.188	.001	.002	3	6
LIVER	ITGB1 →	-1.988	-0.229	<.001	<.001	3	6
SKIN	MCRIP2 →	+1.108	+0.172	<.001	<.001	3	6
LUNG_NSCLC_LUAD	BAG1 →	+1.026	+0.159	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901293 vs DNAJA3 — STOMACH

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