Succinyl-CoA catabolic process

Across TCGA patient cohorts, RNA activity of the Succinyl-CoA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR55, MIR554, and HLA-DQB2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Succinyl-CoA catabolic process activity versus GPR55 in GBM (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GPR55 →	-0.486	-0.069	.004	.001	3	4
LSCC	MIR554 →	+1.193	+0.151	<.001	<.001	3	4
OV	HLA-DQB2 →	-1.351	-0.131	.002	.002	3	4
BRCA	EXPH5 →	+0.692	+0.135	<.001	.001	3	4
HNSC	PM20D2 →	+0.930	+0.111	<.001	<.001	3	4
COAD	CEL →	+1.587	+0.123	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901289 vs GPR55 — GBM

Explore this scatter interactively →