Carbohydrate derivative transport

Across TCGA patient cohorts, RNA activity of the Carbohydrate derivative transport pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAMHD1, SAAL1, and SPN_S368, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carbohydrate derivative transport activity versus SAMHD1 in UCEC (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SAMHD1 →	+0.599	+0.062	<.001	<.001	3	7
GBM	SAAL1 →	-0.492	-0.028	<.001	.002	3	6
GBM	SPN_S368 →	+0.484	+0.028	.002	<.001	3	6
LUAD	DOCK2_S1706 →	+0.745	+0.032	.009	.001	3	6
GBM	HCLS1 →	+0.608	+0.035	<.001	<.001	3	6
GBM	LAIR1 →	+0.713	+0.030	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901264 vs SAMHD1 — UCEC

Explore this scatter interactively →