Carbohydrate derivative transport

Across TCGA cell cohorts, RNA activity of the Carbohydrate derivative transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GBP3, LEPROT, and SAMD9L, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carbohydrate derivative transport activity versus GBP3 in LUNG_NSCLC_LUSC (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GBP3 →	+3.922	+0.546	.003	<.001	2	12
LIVER	LEPROT →	+1.622	+0.508	.004	<.001	3	9
BONE	SAMD9L →	+2.064	+0.470	<.001	.001	3	8
SOFT_TISSUE	CD274 →	+2.070	+0.342	.007	.002	3	8
BONE	APOL1 →	+2.994	+0.642	.004	.001	3	8
BONE	THBS1 →	+6.093	+0.516	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901264 vs GBP3 — LUNG_NSCLC_LUSC

Explore this scatter interactively →