Negative regulation of non-canonical NF-kappaB signal transduction

Across TCGA patient cohorts, RNA activity of the Negative regulation of non-canonical NF-kappaB signal transduction pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ILK, CNN2, and DCN, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of non-canonical NF-kappaB signal transduction activity versus ILK in BRCA (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ILK →	+0.339	+0.025	<.001	<.001	3	9
GBM	CNN2 →	+0.551	+0.037	<.001	<.001	3	8
GBM	DCN →	+0.830	+0.054	.004	<.001	3	8
UCEC	KCTD12 →	+0.440	+0.053	<.001	<.001	3	8
CCRCC	SERPINA5 →	+0.580	+0.067	<.001	<.001	3	7
OV	RSBN1L →	-0.308	-0.039	.008	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901223 vs ILK — BRCA

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