Regulation of non-canonical NF-kappaB signal transduction

Across TCGA patient cohorts, RNA activity of the Regulation of non-canonical NF-kappaB signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CACYBP, NDUFB9, and RAC3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of non-canonical NF-kappaB signal transduction activity versus CACYBP in LSCC (Pearson r = -0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CACYBP →	-0.485	-0.134	.002	<.001	3	5
GBM	NDUFB9 →	-0.326	-0.195	<.001	.001	3	5
LSCC	RAC3 →	-0.888	-0.165	<.001	<.001	3	5
LUAD	FXR2 →	-0.392	-0.116	<.001	<.001	3	5
LUAD	WRAP53 →	-0.284	-0.097	.006	.001	3	5
LSCC	NCKIPSD →	-0.457	-0.154	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901222 vs CACYBP — LSCC

Explore this scatter interactively →