Positive regulation of extracellular matrix assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of extracellular matrix assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPB41, AACS, and SH3GL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EPB41 grouped by Positive regulation of extracellular matrix assembly-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EPB41 →	+1.537	+1.052	.002	.005	3	5
LUNG_SCLC	AACS →	+1.334	+1.342	.002	.001	3	5
LIVER	SH3GL1 →	-0.695	-1.360	.003	<.001	3	4
BLOOD_Leukemia	KLHL23 →	+1.359	+1.286	<.001	<.001	3	4
LARGE_INTESTINE	MYB →	+1.994	+0.758	<.001	.006	3	4
LUNG_SCLC	MNX1 →	+1.312	+1.213	.009	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EPB41 by Positive regulation of extracellular matrix assembly activity — BLOOD_Leukemia

Explore this box plot interactively →