Regulation of extracellular matrix assembly

Across TCGA cell cohorts, RNA activity of the Regulation of extracellular matrix assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLF12, CDCA4, and APOO, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of extracellular matrix assembly activity versus KLF12 in BLOOD_Leukemia (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KLF12 →	+1.654	+0.657	<.001	.006	3	4
PANCREAS	CDCA4 →	+0.957	+0.532	<.001	<.001	3	3
STOMACH	APOO →	+0.903	+0.442	<.001	<.001	3	3
URINARY_TRACT	GALNT3 →	-3.769	-0.295	<.001	.007	3	3
URINARY_TRACT	NDEL1 →	+0.863	+0.378	<.001	.009	2	4
URINARY_TRACT	AFF4 →	+0.840	+0.404	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901201 vs KLF12 — BLOOD_Leukemia

Explore this scatter interactively →