Positive regulation of ERBB signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of ERBB signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC88A, C1QTNF6, and TMBIM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of ERBB signaling pathway activity versus CCDC88A in PDAC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CCDC88A →	+0.437	+0.798	<.001	<.001	3	5
UCEC	C1QTNF6 →	+0.606	+0.604	<.001	.001	3	5
OV	TMBIM1 →	+0.645	+0.501	<.001	.003	3	5
HNSC	NIPAL4 →	+1.298	+0.523	<.001	<.001	3	5
BRCA	GJB3 →	+1.436	+0.487	.001	.003	3	5
BRCA	SNAI2 →	+0.895	+0.488	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901186 vs CCDC88A — PDAC

Explore this scatter interactively →