Regulation of ERBB signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of ERBB signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STK25, KCTD14, and PRKCG, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STK25 grouped by Regulation of ERBB signaling pathway-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	STK25 →	-0.184	-0.085	.004	.002	2	7
BLOOD_Myeloma	KCTD14 →	+0.168	+0.078	.002	.002	3	5
LARGE_INTESTINE	PRKCG →	-0.157	-0.045	.006	.009	3	5
URINARY_TRACT	ABR →	-0.300	-0.056	<.001	.003	3	5
LUNG_NSCLC_LUSC	GRIK5 →	-0.243	-0.087	.001	<.001	3	5
URINARY_TRACT	FIGNL2 →	-0.198	-0.055	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STK25 by Regulation of ERBB signaling pathway activity — BLOOD_Myeloma

Explore this box plot interactively →