Regulation of ERBB signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of ERBB signaling pathway pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 68 member genes.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher Regulation of ERBB signaling pathway pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LUAD and HNSC, show the opposite pattern, with higher activity associated with better survival.

LUAD, HNSC, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.756	0.460	<.001	74	view →
HNSC	DFS	Tertile	IV	0.549	0.255	<.001	58	view →
ACC	OS	Tertile	All	0.749	0.964	.002	54	view →
KIRC	DFS	Median	All	0.529	0.719	<.001	48	view →
MESO	DFS	Tertile	All	0.258	0.448	.005	40	view →
LIHC	OS	Tertile	All	0.571	0.751	.002	30	view →
UCS	DFS	Tertile	IV	0.861	0.275	.024	24	view →
UVM	DFS	Tertile	III,IV	0.233	0.856	.004	24	view →
KIRP	OS	Median	III,IV	0.136	0.720	.004	22	view →
BRCA	OS	Median	II,III,IV	0.974	0.940	.008	20	view →
SKCM	DFS	Tertile	All	0.276	0.164	.007	16	view →
LUSC	DFS	Quartile	III,IV	0.190	0.951	.004	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:1901184–LUAD (DFS)

Open the LUAD breakdown →