Regulation of ERBB signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of ERBB signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPSTI1, PSIP1, and PELP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ERBB signaling pathway activity versus EPSTI1 in STOMACH (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	EPSTI1 →	+2.500	+0.264	.003	.006	3	6
STOMACH	PSIP1 →	-1.251	-0.287	.007	.002	3	6
OVARY	PELP1 →	-0.791	-0.238	<.001	.002	3	5
SOFT_TISSUE	AK2 →	-0.641	-0.257	.001	.008	3	5
LARGE_INTESTINE	USP46 →	-0.988	-0.181	<.001	.006	3	5
LUNG_NSCLC_LUSC	CHD4 →	-0.705	-0.346	.009	.006	1	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901184 vs EPSTI1 — STOMACH

Explore this scatter interactively →