Negative regulation of trophoblast cell migration

Across TCGA patient cohorts, RNA activity of the Negative regulation of trophoblast cell migration pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C8A, DAB2_S723, and RIN3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of trophoblast cell migration activity versus C8A in COAD (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C8A →	+0.469	+0.051	<.001	<.001	3	8
OV	DAB2_S723 →	+0.903	+0.065	<.001	<.001	3	8
OV	RIN3 →	+0.435	+0.052	<.001	.003	3	7
UCEC	RSU1 →	+0.465	+0.088	<.001	.005	3	7
GBM	SH3PXD2A_T256 →	+0.683	+0.081	.009	.008	3	7
UCEC	SIPA1 →	+0.276	+0.122	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901164 vs C8A — COAD

Explore this scatter interactively →