Negative regulation of signal transduction in absence of ligand

Across TCGA patient cohorts, RNA activity of the Negative regulation of signal transduction in absence of ligand pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PSTPIP2, TNFAIP8L2, and XRCC1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of signal transduction in absence of ligand activity versus PSTPIP2 in COAD (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PSTPIP2 →	+0.494	+0.035	<.001	<.001	3	7
COAD	TNFAIP8L2 →	+0.454	+0.030	<.001	.001	3	6
GBM	XRCC1 →	-0.386	-0.066	<.001	<.001	3	6
COAD	IFIT2 →	+0.627	+0.033	.001	.005	3	6
COAD	MNDA →	+1.019	+0.040	<.001	<.001	3	6
OV	TNFAIP3 →	+0.424	+0.043	.004	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901099 vs PSTPIP2 — COAD

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