Negative regulation of signal transduction in absence of ligand

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of signal transduction in absence of ligand pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 35 member genes.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher Negative regulation of signal transduction in absence of ligand pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and PAAD, show the opposite pattern, with higher activity associated with better survival.

BRCA, CHOL, and PAAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Quartile	III,IV	0.935	0.788	.006	48	view →
CHOL	OS	Median	III,IV	0.286	1.000	.008	25	view →
PAAD	OS	Median	All	0.634	0.399	.012	21	view →
LUSC	DFS	Tertile	II,III,IV	0.609	0.924	.001	20	view →
READ	DFS	Median	III,IV	0.445	0.192	.012	17	view →
LAML	DFS	Quartile	All	0.227	0.500	.003	12	view →
THCA	OS	Median	IV	0.566	0.924	.010	12	view →
HNSC	OS	Median	All	0.510	0.673	.023	7	view →
COAD	DFS	Tertile	IV	0.352	0.569	.034	6	view →
LIHC	DFS	Tertile	II,III,IV	0.294	0.572	.010	6	view →
ACC	OS	Median	IV	0.327	0.633	.045	6	view →
LGG	DFS	Quartile	All	0.633	0.778	.027	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:1901099–BRCA (DFS)

Open the BRCA breakdown →