Negative regulation of signal transduction in absence of ligand

Across TCGA patient cohorts, RNA activity of the Negative regulation of signal transduction in absence of ligand pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NRXN2-AS1, ST6GAL2, and GJA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of signal transduction in absence of ligand activity versus NRXN2-AS1 in LSCC (Pearson r = 0.00).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NRXN2-AS1 →	+0.411	+0.599	.007	.003	3	3
PDAC	ST6GAL2 →	+0.808	+0.425	<.001	<.001	3	3
PDAC	GJA1 →	+0.692	+0.405	<.001	.003	3	3
COAD	HTRA1 →	+0.875	+0.802	.001	.001	3	3
HNSC	CEP295NL →	+0.453	+0.634	.005	.006	3	3
HNSC	MUC21 →	-1.228	-0.485	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901099 vs NRXN2-AS1 — LSCC

Explore this scatter interactively →