Negative regulation of signal transduction in absence of ligand

Across TCGA cell cohorts, RNA activity of the Negative regulation of signal transduction in absence of ligand pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLF3, SCD5, and DOC2A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KLF3 grouped by Negative regulation of signal transduction in absence of ligand-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	KLF3 →	+0.991	+1.457	.002	.009	3	4
SOFT_TISSUE	SCD5 →	+1.439	+0.934	<.001	.004	3	3
OESOPHAGUS	DOC2A →	+1.295	+0.296	.006	.001	3	3
OESOPHAGUS	SYCE1L →	+0.696	+0.307	.007	.004	3	3
SKIN	TWNK →	+0.606	+0.988	<.001	<.001	3	3
SOFT_TISSUE	FIG4 →	-1.060	-1.191	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KLF3 by Negative regulation of signal transduction in absence of ligand activity — BONE

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