Negative regulation of signal transduction in absence of ligand

Across TCGA cell cohorts, RNA activity of the Negative regulation of signal transduction in absence of ligand pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL2L1, STK17A, and LAMB3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of signal transduction in absence of ligand activity versus BCL2L1 in SOFT_TISSUE (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	BCL2L1 →	+2.156	+0.833	.001	.003	3	7
STOMACH	STK17A →	+1.594	+1.482	.003	.004	3	4
STOMACH	LAMB3 →	+5.535	+2.238	.003	.002	3	4
LARGE_INTESTINE	CAV2 →	+4.203	+1.055	<.001	.007	3	3
LARGE_INTESTINE	ARHGAP29 →	+2.639	+0.741	<.001	.008	3	3
LARGE_INTESTINE	ADAMTS16 →	+0.991	+1.139	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901099 vs BCL2L1 — SOFT_TISSUE

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