Negative regulation of autophagosome maturation

Across TCGA patient cohorts, RNA activity of the Negative regulation of autophagosome maturation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBED4, NINL, and SYTL5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of autophagosome maturation activity versus ZBED4 in CCRCC (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ZBED4 →	-0.277	-0.609	.001	.001	3	3
CCRCC	NINL →	-0.407	-0.743	.001	.001	3	3
CCRCC	SYTL5 →	-0.457	-0.573	.002	.004	3	3
LUAD	PLXNB1 →	-0.458	-0.696	.007	<.001	3	3
CCRCC	SNORD89 →	+0.831	+0.527	<.001	.005	2	4
CCRCC	ARL16 →	-0.261	-0.529	.006	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901097 vs ZBED4 — CCRCC

Explore this scatter interactively →