Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARAF, COL3A1_S1120, and ADAT1_S191, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway activity versus ARAF in GBM (Pearson r = -0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARAF →	-0.249	-0.055	<.001	<.001	3	4
OV	COL3A1_S1120 →	+1.274	+0.046	.001	<.001	3	4
CCRCC	ADAT1_S191 →	-0.426	-0.033	.001	.001	3	4
LUAD	GSTZ1 →	-0.378	-0.030	.001	.007	3	4
LUAD	MAP3K7_S417 →	-0.512	-0.037	.001	.002	3	4
LSCC	CROCC_S512 →	-0.497	-0.041	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901030 vs ARAF — GBM

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