Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

pathway activity — tumor vs normal
GO:1901030Tumor vs NormalRNA activityBox plot · TCGA cohorts

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway pathway differs between tumor and matched normal tissue in 11 of the 18 cancer types tested.

The strongest signal is observed in colon adenocarcinoma (COAD), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors.

COAD, STAD, and BLCA show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log2 scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.
LineageGenderStageActivity changepSampling consensus
COADFemaleAll+0.052<.00110view →
STADFemaleAll+0.107<.0018view →
BLCAAllAll+0.056.0058view →
LIHCFemaleAll+0.049<.0018view →
KIRCMaleIV+0.042<.0018view →
HNSCAllAll+0.024.0067view →
UCECAllAll+0.056<.0016view →
KIRPMaleAll+0.045<.0016view →
BRCAAllAll+0.020.0024view →
READAllAll+0.069.0013view →
CHOLMaleAll+0.111<.0012view →
Pink = more active in tumor, green = less active in tumor. Showing the 11 strongest of 11 lineages.

GO:1901030–COAD

Tumor-vs-normal pathway-activity box plot for Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway in COAD.

Open the COAD breakdown →

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