Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAV32, DOT1L, and SMG7-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway activity versus TRAV32 in CCRCC (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TRAV32 →	+1.075	+0.358	.008	.007	3	4
HNSC	DOT1L →	-0.488	-0.216	.003	<.001	3	3
HNSC	SMG7-AS1 →	-0.536	-0.171	.005	.001	3	3
LUAD	GPA33 →	+0.552	+0.145	.003	.009	3	3
LUAD	METTL7B →	+0.805	+0.170	.004	.002	3	3
LUAD	ETFDH →	+0.309	+0.168	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901030 vs TRAV32 — CCRCC

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