Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LDLRAD3, PMS2, and SLC2A3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway activity versus LDLRAD3 in BLOOD_Lymphoma (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LDLRAD3 →	-1.486	-0.367	<.001	.002	3	5
OESOPHAGUS	PMS2 →	-1.082	-0.450	.002	.002	3	4
BLOOD_Lymphoma	SLC2A3 →	-2.896	-0.336	<.001	.005	2	5
OVARY	TUBA4A →	+3.368	+0.353	<.001	.001	3	4
BLOOD_Lymphoma	BDH1 →	+2.667	+0.397	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	GPHN →	-1.271	-0.227	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901030 vs LDLRAD3 — BLOOD_Lymphoma

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