Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACAA2, ZADH2, and PAX9, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway activity versus ACAA2 in LUNG_NSCLC_LUSC (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ACAA2 →	+2.841	+0.322	.004	.001	3	12
URINARY_TRACT	ZADH2 →	+1.044	+0.207	.001	.003	3	5
URINARY_TRACT	PAX9 →	-1.410	-0.221	.003	.006	3	5
BLOOD_Leukemia	TSSK6 →	-0.632	-0.182	.006	.005	3	5
STOMACH	NDEL1 →	-1.078	-0.290	.009	.003	3	5
KIDNEY	DNAJC19 →	-0.848	-0.243	.006	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901029 vs ACAA2 — LUNG_NSCLC_LUSC

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