Negative regulation of calcium ion transmembrane transporter activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of calcium ion transmembrane transporter activity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEAD2, STIL, and ENOX2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of calcium ion transmembrane transporter activity activity versus TEAD2 in BLOOD_Lymphoma (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TEAD2 →	+1.128	+0.231	.005	.004	3	3
BREAST	STIL →	+0.884	+0.439	<.001	.007	3	3
BREAST	ENOX2 →	+0.898	+0.434	<.001	.007	3	3
BREAST	TOPORS →	+0.733	+0.437	<.001	.007	3	3
LUNG_SCLC	ENG →	-1.568	-0.162	.002	.004	3	3
LUNG_SCLC	GTF2A1 →	+1.071	+0.261	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901020 vs TEAD2 — BLOOD_Lymphoma

Explore this scatter interactively →