Regulation of potassium ion transmembrane transporter activity

pathway activity — cross-omics
GO:1901016Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Regulation of potassium ion transmembrane transporter activity pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDR13, AQR, and TNS1_S1400, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCAWDR13 →+0.189+0.034<.001<.00137
BRCAAQR →-0.170-0.027.001.00537
HNSCTNS1_S1400 →+0.608+0.034<.001<.00137
BRCASH3D19 →+0.413+0.032<.001<.00136
PDACTELO2 →-0.449-0.040<.001<.00136
BRCASERPINA5 →+0.685+0.037<.001<.00136
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration