Positive regulation of p38MAPK cascade

Across TCGA patient cohorts, RNA activity of the Positive regulation of p38MAPK cascade pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFRSF10C, PTAFR, and MIR223HG, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of p38MAPK cascade activity versus TNFRSF10C in LUAD (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TNFRSF10C →	+0.852	+0.805	.002	.009	3	5
UCEC	PTAFR →	+0.770	+0.419	<.001	.001	3	5
UCEC	MIR223HG →	+0.874	+0.479	<.001	.005	3	5
UCEC	SLC11A1 →	+0.864	+0.534	<.001	.003	3	5
HNSC	PDZK1IP1 →	+1.618	+0.293	<.001	.004	3	4
UCEC	SIRPB1 →	+0.675	+0.581	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900745 vs TNFRSF10C — LUAD

Explore this scatter interactively →