Positive regulation of p38MAPK cascade

Across TCGA cell cohorts, RNA activity of the Positive regulation of p38MAPK cascade pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DSC2, PWWP2A, and THAP10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of p38MAPK cascade activity versus DSC2 in LARGE_INTESTINE (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DSC2 →	+1.858	+0.927	.001	.002	3	4
BLOOD_Leukemia	PWWP2A →	+0.543	+1.233	.002	<.001	3	4
LUNG_NSCLC_LUSC	THAP10 →	+0.936	+1.853	.001	<.001	3	4
LARGE_INTESTINE	ZDHHC6 →	+0.516	+1.063	.009	<.001	3	3
KIDNEY	FSD1L →	+0.814	+1.022	<.001	.006	3	3
KIDNEY	DVL1 →	+1.148	+1.149	.008	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900745 vs DSC2 — LARGE_INTESTINE

Explore this scatter interactively →